Journal article
MC1R genotype as a predictor of early-onset melanoma, compared with self-reported and physician-measured traditional risk factors: An Australian case-control-family study
AE Cust, C Goumas, K Vuong, JR Davies, JH Barrett, EA Holland, H Schmid, C Agha-Hamilton, BK Armstrong, RF Kefford, JF Aitken, GG Giles, DT Bishop, JA Newton-Bishop, JL Hopper, GJ Mann, MA Jenkins
BMC Cancer | BMC | Published : 2013
Abstract
Background: Melanocortin-1 receptor (MC1R) gene variants are very common and are associated with melanoma risk, but their contribution to melanoma risk prediction compared with traditional risk factors is unknown. We aimed to 1) evaluate the separate and incremental contribution of MC1R genotype to prediction of early-onset melanoma, and compare this with the contributions of physician-measured and self-reported traditional risk factors, and 2) develop risk prediction models that include MC1R, and externally validate these models using an independent dataset from a genetically similar melanoma population.Methods: Using data from an Australian population-based, case-control-family study, we i..
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Awarded by University of Sydney
Funding Acknowledgements
This work was supported by the National Health and Medical Research Council of Australia (NHMRC) (project grants 566946, 107359, 211172 and program grant number 402761 to GJM and RFK); the Cancer Council New South Wales (project grant 77/00, 06/10), the Cancer Council Victoria and the Cancer Council Queensland (project grant 371); the US National Institutes of Health (via NIH RO1 grant CA-83115-01A2 to the international Melanoma Genetics Consortium - GenoMEL) and a Victorian Cancer Agency Early Career Seed Grant (ECSG07_010). AEC is the recipient of a NHMRC public health postdoctoral fellowship (520018) and a Cancer Institute NSW Early Career Development Fellowship (10/ECF/2-06). BKA's research is supported by a University of Sydney Medical Foundation Program Grant and JLH is an Australia Fellow of the NHMRC. For the English case-control study (Melanoma Cohort Study), the collection of samples was funded by Cancer Research UK (Project Grant C8216/A6129 and Program awards C588/A4994 and C588/A10589) and by the NIH (R01 CA83115). None of the funding bodies had a role in the design, collection, analysis, or interpretation of data, in the writing of the manuscript, or the decision to submit the manuscript for publication.